Role of lipopolysaccharide in regulating colony-stimulating factor-dependent macrophage proliferation in vitro

URN to cite this document:: urn:nbn:de:bvb:355-epub-212055
DOI to cite this document:: 10.5283/epub.21205

Moore, R. N. ; Steeg, P. S. ; Männel, D. N. ; Mergenhagen, S. E.

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Date of publication of this fulltext: 22 Jun 2011 08:10

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Abstract

Bacterial lipopolysaccharides (LPS) enhance both production of colony-stimulating factors (CSF) and proliferation of mononuclear phagocytes in vivo. The present study was undertaken to determine whether the effects of LPS on CSF-dependent monopoiesis are due solely to enhanced production of CSF or also to direct effects of LPS on the responding progenitor cell. Addition of LPS to CSF-stimulated ...