Induction of cytolytic T lymphocytes directed towards the V3 loop of the human immunodeficiency virus type 1 external glycoprotein gp120 by p55gag/V3 chimeric vaccinia viruses

URN to cite this document:: urn:nbn:de:bvb:355-epub-217612
DOI to cite this document:: 10.5283/epub.21761

Wagner, Ralf ; Böltz, T. ; Deml, Ludwig ; Modrow, Susanne ; Wolf, Hans J.

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Date of publication of this fulltext: 12 Aug 2011 08:57

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Abstract

T cell-mediated cytotoxicity may play an important role in controlling infection by human immunodeficiency virus (HIV). In order to study the ability of rationally designed antigens to induce cytolytic T lymphocytes (CTLs) we replaced stretches of 30 to 50 amino acids at the p17-MA/p24-CA cleavage site, within the p24-CA moiety and within the p6-LI portion of the HIV type 1 p55gag precursor by ...