A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes

URN to cite this document:: urn:nbn:de:bvb:355-epub-221496
DOI to cite this document:: 10.5283/epub.22149

Bucher, Joachim ; Riedmaier, Stephan ; Schnabel, Anke ; Marcus, Katrin ; Vacun, Gabriele ; Weiss, Thomas S.

; Thasler, Wolfgang E. ; Nüssler, Andreas K. ; Zanger, Ulrich M.

; Reuss, Matthias

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Date of publication of this fulltext: 26 Sep 2011 09:39

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Abstract

Background: The individual character of pharmacokinetics is of great importance in the risk assessment of new drug leads in pharmacological research. Amongst others, it is severely influenced by the properties and inter-individual variability of the enzymes and transporters of the drug detoxification system of the liver. Predicting individual drug biotransformation capacity requires quantitative ...