A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes

URN to cite this document:: urn:nbn:de:bvb:355-epub-221496
DOI to cite this document:: 10.5283/epub.22149

Bucher, Joachim ; Riedmaier, Stephan ; Schnabel, Anke ; Marcus, Katrin ; Vacun, Gabriele ; Weiss, Thomas S.

; Thasler, Wolfgang E. ; Nüssler, Andreas K. ; Zanger, Ulrich M. ; Reuss, Matthias

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Date of publication of this fulltext: 26 Sep 2011 09:39

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Abstract

A dynamic model for the biotransformation of atorvastatin has been developed using quantitative metabolite measurements in primary human hepatocytes. The model comprises kinetics for transport processes and metabolic enzymes as well as population liver expression data allowing us to assess the impact of inter-individual variability of concentrations of key proteins. Application of computational ...