Evolution and functional divergence of the anoctamin family of membrane proteins

URN to cite this document:: urn:nbn:de:bvb:355-epub-221958
DOI to cite this document:: 10.5283/epub.22195

Milenkovic, Vladimir M. ; Brockmann, Marisa

; Stöhr, Heidi ; Weber, Bernhard H. F.

; Strauss, Olaf

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Date of publication of this fulltext: 26 Sep 2011 09:51

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Abstract

Background: The anoctamin family of transmembrane proteins are found in all eukaryotes and consists of 10 members in vertebrates. Ano1 and ano2 were observed to have Ca(2+) activated Cl-channel activity. Recent findings however have revealed that ano6, and ano7 can also produce chloride currents, although with different properties. In contrast, ano9 and ano10 suppress baseline Cl-conductance when ...