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Evolution and functional divergence of the anoctamin family of membrane proteins

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Milenkovic, Vladimir M. ; Brockmann, Marisa ; Stöhr, Heidi ; Weber, Bernhard H. F. ; Strauss, Olaf
License: Creative Commons: Attribution 3.0
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Date of publication of this fulltext: 26 Sep 2011 09:51


Our study suggests that anoctamins have evolved by series of duplication events, and that they are constrained by purifying selection. In addition we identified a number of protein domains, and amino acid residues which contribute to predicted functional divergence. Hopefully, this work will facilitate future functional characterization of the anoctamin membrane protein family.

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