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Antitumor Activity of Cell Wall β-1,3/1,6-Glucans from Phytophthora Species

Kraus, J. ; Blaschek, W. ; Schütz, M. ; Franz, Gerhard


From the cell walls of various Phytophthora species (Oomycetes) different water-soluble β-1,3/1,6-glucans were isolated and characterized. The glucans with relative molecular masses between 13 and 50 kd exhibited varying degrees of branching in the β-1,3-linked glucan backbone ranging from 14 to 50%. The dose-dependent antitumor activity of the glucans against allogeneic sarcoma-180 was ...


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