Goppelt-Struebe, M. and Franz, Gerhard
(2004)
Stability control of valerian ground material and extracts: a new HPLC-method for the routine quantification of valerenic acids and lignans.
Die Pharmazie 59 (6), pp. 446-452.
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Abstract
A new HPLC-method for the separation of medium polar and nonpolar compounds in preparations of Valeriana officinalis was established for stability control. Powdered valerian root and a commercial ethanolic valerian extract were investigated for apparent differences in stability behaviour. Storage conditions were chosen according to the ICH-guidelines. Changes in composition of valerenic acids and ...
Abstract
A new HPLC-method for the separation of medium polar and nonpolar compounds in preparations of Valeriana officinalis was established for stability control. Powdered valerian root and a commercial ethanolic valerian extract were investigated for apparent differences in stability behaviour. Storage conditions were chosen according to the ICH-guidelines. Changes in composition of valerenic acids and lignans were observed depending on storage conditions and packaging materials. Hydroxyvalerenic acid, pinoresinol and hydroxypinoresinol were identified as degradation products in Valerian root, especially during accelerated testing. Ethanolic extracts appeared not to be as sensitive for chemical degradation under climatic influences compared to the crude plant material, and showed no increase in the amounts of lignan-aglyka. In comparison, extracts showed high sensitivity on changes of physical properties like loss on drying and viscosity.
Export bibliographical data
| Item type: | Article |
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| Date: | 2004 |
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| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Franz |
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| Identification Number: | | Value | Type |
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| 15248459 | PubMed ID |
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| Classification: | | Notation | Type |
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| Chromatography, High Pressure Liquid | MESH | | Chromatography, Thin Layer | MESH | | Desiccation | MESH | | Drug Packaging | MESH | | Drug Stability | MESH | | Drug Storage | MESH | | Indenes/standards | MESH | | Lignans | MESH | | Phytotherapy/standards | MESH | | Plant Extracts/chemistry | MESH | | Plant Roots/chemistry | MESH | | Sesquiterpenes/standards | MESH | | Valerian/chemistry | MESH |
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| Dewey Decimal Classification: | 500 Science > 540 Chemistry & allied sciences |
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| Status: | Published |
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| Refereed: | Yes, this version has been refereed |
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| Created at the University of Regensburg: | Unknown |
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| Item ID: | 22569 |
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