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Inhibition of PMN-elastase activity by semisynthetic glucan sulfates

Becker, Markus ; Franz, Gerhard ; Alban, Susanne


Proteolysis of connective tissue by enzymes such as PMN-elastase(PMNE) is a crucial step during inflammation and metastasis.Semisynthetic sulfated carbohydrates (SC) were shown toexhibit potent antiinflammatory and antimetastatic activity invivo. The aim of the present study was to examine whetherinterferences with PMN-elastase may contribute to theseeffects. Therefore, the interactions of these ...


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