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Inhibition of PMN-elastase activity by semisynthetic glucan sulfates

Becker, Markus, Franz, Gerhard and Alban, Susanne (2003) Inhibition of PMN-elastase activity by semisynthetic glucan sulfates. Thrombosis and Haemostasis 89, pp. 915-925.

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Proteolysis of connective tissue by enzymes such as PMN-elastase(PMNE) is a crucial step during inflammation and metastasis.Semisynthetic sulfated carbohydrates (SC) were shown toexhibit potent antiinflammatory and antimetastatic activity invivo. The aim of the present study was to examine whetherinterferences with PMN-elastase may contribute to theseeffects. Therefore, the interactions of these ...


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Item type:Article
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Franz
Keywords:PMN-elastase, glucan sulfates, heparin, inflammation, metastasis
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Created at the University of Regensburg:Unknown
Item ID:22843
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