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Die Synthese verschiedener Carbonsäuren durch den Multienzymkomplex der Fettsäuresynthese aus Hefe und die Erklärung ihrer Bildung [ = Synthesis of various carboxylic acids by the fatty acid synthetase multienzyme complex of yeast and the explanation for their structure]

Sumper, Manfred, Oesterhelt, D., Riepertinger, C. and Lynen, F. (1969) Die Synthese verschiedener Carbonsäuren durch den Multienzymkomplex der Fettsäuresynthese aus Hefe und die Erklärung ihrer Bildung [ = Synthesis of various carboxylic acids by the fatty acid synthetase multienzyme complex of yeast and the explanation for their structure]. European journal of biochemistry / FEBS 10 (2), pp. 377-387.

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Abstract

The purified multienzyme complex, fatty acid synthetase of yeast, produces palmityl-CoA and stearyl-CoA in equal amounts under standard conditions, with adequate NADPH, and a 1:2 ratio of acetyl-CoA and malonyl-CoA. Based on the known enzymatic properties of fatty acid synthetase a model which rationalizes the chain termination at the level of C16 and C18-acid is proposed. The model is based ...

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Item type:Article
Date:1969
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Alumni or Retired > Prof. Dr. Manfred Sumper
Identification Number:
ValueType
4390422PubMed ID
10.1111/j.1432-1033.1969.tb00701.xDOI
Classification:
NotationType
Carbon IsotopesMESH
Chromatography, GasMESH
Coenzyme A/metabolismMESH
Fatty Acids/biosynthesisMESH
Glucosephosphate Dehydrogenase/metabolismMESH
Keto Acids/biosynthesisMESH
KineticsMESH
Ligases/metabolismMESH
Malonates/metabolismMESH
Models, ChemicalMESH
NAD/metabolismMESH
NADP/metabolismMESH
Palmitic Acids/biosynthesisMESH
Saccharomyces/enzymologyMESH
Stearic Acids/biosynthesisMESH
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:22935
Owner only: item control page

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