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Die Synthese verschiedener Carbonsäuren durch den Multienzymkomplex der Fettsäuresynthese aus Hefe und die Erklärung ihrer Bildung [ = Synthesis of various carboxylic acids by the fatty acid synthetase multienzyme complex of yeast and the explanation for their structure]

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Sumper, Manfred ; Oesterhelt, D. ; Riepertinger, C. ; Lynen, F.
Date of publication of this fulltext: 13 Dec 2011 06:41


The purified multienzyme complex, fatty acid synthetase of yeast, produces palmityl-CoA and stearyl-CoA in equal amounts under standard conditions, with adequate NADPH, and a 1:2 ratio of acetyl-CoA and malonyl-CoA. Based on the known enzymatic properties of fatty acid synthetase a model which rationalizes the chain termination at the level of C16 and C18-acid is proposed. The model is based ...


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