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Impact of tumor necrosis factor receptor-1 signalling to Listeria monocytogenes-containing phagosomes
and its role for bacterial eradication

Heigl, Ulrike (2013) Impact of tumor necrosis factor receptor-1 signalling to Listeria monocytogenes-containing phagosomes
and its role for bacterial eradication.
PhD, Universität Regensburg.

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Date of publication of this fulltext: 22 Jan 2013 17:03

Abstract (English)

The contribution of tumor necrosis factor alpha (TNF alpha) and tumor necrosis factor receptor-1 (TNF-R1) to the eradication process of intracellular bacteria is well-known and undisputed. Mice deficient in TNF-R1 or components of TNF-R1 signalling (acid sphingomyelinase or ASMase) were strongly impaired in their capacity to kill Listeria monocytogenes (L.m.) and died upon infection with low ...

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Translation of the abstract (German)

Die Abwehr intrazellulärer Erreger wie Listeria monocytogenes (L.m.) erfolgt unter Beteiligung des Zytokins TNF alpha und seines Rezeptors TNF-R1. Dies konnte an Mäusen gezeigt werden, die entweder defizient für den TNF-R1 sind, oder Defekte in der TNF alpha-vermittelten Aktivierung von Proteasen, z.B. der sauren Sphingomyelinase (ASMase), aufweisen und deshalb die Infektion nicht mehr ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:22 January 2013
Referee:PD Dr. Wulf Schneider
Date of exam:28 October 2011
Institutions:Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Interdisciplinary Subject Network:Not selected
Keywords:TNFR1- signalling, TNF alpha, Phagosomen, Phagolysosom, bakterielle Abwehr, Listeria monocytogenes
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:23024
Owner only: item control page

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