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Impact of tumor necrosis factor receptor-1 signalling to Listeria monocytogenes-containing phagosomes
and its role for bacterial eradication

URN to cite this document:
urn:nbn:de:bvb:355-epub-230249
Heigl, Ulrike
Date of publication of this fulltext: 22 Jan 2013 17:03


Abstract (English)

The contribution of tumor necrosis factor alpha (TNF alpha) and tumor necrosis factor receptor-1 (TNF-R1) to the eradication process of intracellular bacteria is well-known and undisputed. Mice deficient in TNF-R1 or components of TNF-R1 signalling (acid sphingomyelinase or ASMase) were strongly impaired in their capacity to kill Listeria monocytogenes (L.m.) and died upon infection with low ...

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Translation of the abstract (German)

Die Abwehr intrazellulärer Erreger wie Listeria monocytogenes (L.m.) erfolgt unter Beteiligung des Zytokins TNF alpha und seines Rezeptors TNF-R1. Dies konnte an Mäusen gezeigt werden, die entweder defizient für den TNF-R1 sind, oder Defekte in der TNF alpha-vermittelten Aktivierung von Proteasen, z.B. der sauren Sphingomyelinase (ASMase), aufweisen und deshalb die Infektion nicht mehr ...

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