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Impact of tumor necrosis factor receptor-1 signalling to Listeria monocytogenes-containing phagosomes
and its role for bacterial eradication

URN to cite this document:
Heigl, Ulrike
Date of publication of this fulltext: 22 Jan 2013 17:03

Abstract (English)

The contribution of tumor necrosis factor alpha (TNF alpha) and tumor necrosis factor receptor-1 (TNF-R1) to the eradication process of intracellular bacteria is well-known and undisputed. Mice deficient in TNF-R1 or components of TNF-R1 signalling (acid sphingomyelinase or ASMase) were strongly impaired in their capacity to kill Listeria monocytogenes (L.m.) and died upon infection with low ...


Translation of the abstract (German)

Die Abwehr intrazellulärer Erreger wie Listeria monocytogenes (L.m.) erfolgt unter Beteiligung des Zytokins TNF alpha und seines Rezeptors TNF-R1. Dies konnte an Mäusen gezeigt werden, die entweder defizient für den TNF-R1 sind, oder Defekte in der TNF alpha-vermittelten Aktivierung von Proteasen, z.B. der sauren Sphingomyelinase (ASMase), aufweisen und deshalb die Infektion nicht mehr ...


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