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Synthesis, applications and conformational investigations of Neuropeptide Y analogues containing 2-(2-aminocyclopentyl) acetic acid and trans-pentacin

Di Stefano, Pietro (2013) Synthesis, applications and conformational investigations of Neuropeptide Y analogues containing 2-(2-aminocyclopentyl) acetic acid and trans-pentacin. PhD, Universität Regensburg.

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Date of publication of this fulltext: 03 Sep 2013 14:13

Abstract (English)

In this work conformationally constrained gamma-amino acids in which the backbone is constrained by a five-membered ring have been prepared and utilized as building blocks in the design of NPY analogues. Stereoisomers of 2-(2-Fmoc-amino cyclopentyl) acetic acid were synthesized in enantiomerically pure form. NPY analogues containing isomers of the 2-(2-amino cyclopentyl) acetic acid and in ...

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Translation of the abstract (German)

Im Rahmen dieser Arbeit wurden konformativ limitierte gamma-Aminosäuren, in denen das Rückgrat durch einen rigiden fünfgliedrigen Ring eingeschränkt ist, dargestellt und als Bausteine für das Design von NPY analoga verwendet. Stereoisomere von 2-(2-Fmoc-amino cyclopentyl) Essigsäure wurden in enantiomerenreiner Form dargestellt. NPY analoga, die Isomere von 2-(2-amino cyclopentyl) Essigsäure und ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:3 September 2013
Referee:Prof. Dr. Oliver Reiser
Date of exam:30 July 2012
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser
Keywords:Neuropeptide Y, unnatural amino acids, nuclear magnetic resonance
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:25600
Owner only: item control page

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