E3-14.7K Is Recruited to TNF-Receptor 1 and Blocks TNF Cytolysis Independent from Interaction with Optineurin

URN to cite this document:: urn:nbn:de:bvb:355-epub-258573
DOI to cite this document:: 10.5283/epub.25857

Klingeisen, Laura ; Ehrenschwender, Martin

; Heigl, Ulrike ; Wajant, Harald

; Hehlgans, Thomas ; Schütze, Stefan ; Schneider-Brachert, Wulf

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Date of publication of this fulltext: 07 Sep 2012 07:02

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Abstract

Escape from the host immune system is essential for intracellular pathogens. The adenoviral protein E3-14.7K (14.7K) is known as a general inhibitor of tumor necrosis factor (TNF)-induced apoptosis. It efficiently blocks TNF-receptor 1 (TNFR1) internalization but the underlying molecular mechanism still remains elusive. Direct interaction of 14.7K and/or associated proteins with the TNFR1 complex ...