Bründl, Johannes (2012) Mesenchymal stem cell grafts promote oligodendroglial differentiation after spinal cord injury. PhD, Universität Regensburg.
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Abstract (English)
Transplantation of MSC into the acute injured spinal cord is sufficient to enhance oligodendroglial differentiation of endogenous spinal cord progenitor cells up to one month post-injury. Results from the present study and previously published data confirm that underyling mechanisms are based on (a) soluble factor(s) secreted by MSC, which create a specific microenvironment supporting ...
Translation of the abstract (German)
Im Rahmen traumatischer Rückenmarkverletzungen kommt es regelmäßig zu schweren und permanenten neurologischen Funktionsstörungen bzw. -ausfällen. Der irreversible Verlust ortsständiger Rückenmarkzellen einschließlich Neuronen, Astrozyten und Oligodendrozyten sowie die damit einhergehenden ausgeprägten strukturellen Veränderungen repräsentieren das morphologische Korrelat für die schweren ...
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| Item type: | Thesis of the University of Regensburg (PhD) |
|---|---|
| Date: | 5 October 2012 |
| Referee: | Prof. Dr. Norbert Weidner and Prof. Dr. Peter Angele |
| Date of exam: | 2 October 2012 |
| Institutions: | Medicine > Lehrstuhl für Neurologie |
| Keywords: | Mesenchymal, stem cell, transplantation, spinal cord injury, endogenous differentiation |
| Dewey Decimal Classification: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Status: | Published |
| Refereed: | Yes, this version has been refereed |
| Created at the University of Regensburg: | Yes |
| Item ID: | 25994 |
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