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Hepatic steatosis causes induction of the chemokine RANTES in the absence of significant hepatic inflammation

Nießen, Christoph (2012) Hepatic steatosis causes induction of the chemokine RANTES in the absence of significant hepatic inflammation. PhD, Universität Regensburg.

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Date of publication of this fulltext: 25 Oct 2012 09:02

Abstract (English)

Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum ranging from simple steatosis to cirrhosis. Hepatocellular lipid accumulation is a hallmark of both nonalcoholic steatosis and steatohepatitis (NASH). The latter develops upon pro-inflammatory cell infiltration and is widely considered as the first relevant pathophysiological step in NAFLD-progression. The chemokine CCL5/RANTES plays ...

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Translation of the abstract (German)

Einführung Die nicht-alkoholische Fettlebererkrankung beschreibt ein weites Spektrum von Erkrankungen, das von einfacher Leberverfettung (Steatosis) bis zu nichtalkoholischer Steatohepatitis, die mit als Hauptursache der nicht-cholestatischen Leberzirrhose und damit als Vorstufe eines Leberzellkarzinomes gilt. Die genaue Ursache der nicht-alkoholischen Fettleberhepatitis ist nicht genau bekannt. ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:25 October 2012
Referee:Prof. Dr. Claus Hellerbrand and Prof. Dr. Andreas Schreyer
Date of exam:9 October 2012
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Keywords:NAFLD, RANTES, Steatosis hepatis
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:26531
Owner only: item control page

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