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microRNAs associated with the different human Argonaute proteins

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DOI to cite this document:
Dueck, Anne ; Ziegler, Christian ; Eichner, Alexander ; Berezikov, Eugene ; Meister, Gunter
License: Creative Commons: Attribution-Noncommercial 3.0
PDF - Published Version
Date of publication of this fulltext: 24 Oct 2012 10:27


MicroRNAs (miRNAs) are small noncoding RNAs that function in literally all cellular processes. miRNAs interact with Argonaute (Ago) proteins and guide them to specific target sites located in the 3′-untranslated region (3′-UTR) of target mRNAs leading to translational repression and deadenylation-induced mRNA degradation. Most miRNAs are processed from hairpin-structured precursors by the ...


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