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microRNAs associated with the different human Argonaute proteins

URN to cite this document:
urn:nbn:de:bvb:355-epub-265544
Dueck, Anne ; Ziegler, Christian ; Eichner, Alexander ; Berezikov, Eugene ; Meister, Gunter
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License: Creative Commons Attribution Non-commercial 3.0
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Date of publication of this fulltext: 24 Oct 2012 10:27


Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that function in literally all cellular processes. miRNAs interact with Argonaute (Ago) proteins and guide them to specific target sites located in the 3′-untranslated region (3′-UTR) of target mRNAs leading to translational repression and deadenylation-induced mRNA degradation. Most miRNAs are processed from hairpin-structured precursors by the ...

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