Chronic Subordinate Colony Housing (CSC) as a Model of Chronic Psychosocial Stress in Male Rats

URN to cite this document:: urn:nbn:de:bvb:355-epub-275154
DOI to cite this document:: 10.5283/epub.27515

Nyuyki, Kewir D. ; Beiderbeck, Daniela Ingeborg ; Lukas, Michael ; Neumann, Inga D. ; Reber, Stefan Oskar

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Date of publication of this fulltext: 30 Jan 2013 14:04

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Abstract

Chronic subordinate colony housing (CSC) is an adequate and reliable mouse model of chronic psychosocial stress, resulting in reduced body weight gain, reduced thymus and increased adrenal weight, long-lasting anxiety-like behaviour, and spontaneous colitis. Furthermore, CSC mice show increased corticotrophin (ACTH) responsiveness to acute heterotypic stressors, suggesting a general mechanism ...