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Targeting mitochondria by mitochondrial fusion, mitochondria-specific peptides and nanotechnology

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Heller, Anne Sabine
Date of publication of this fulltext: 12 Mar 2013 17:09

Abstract (English)

This thesis was focused on mitochondria as an intracellular target for drug delivery by the reason that mitochondria are becoming of increasing interest in pharmaceutical and medical research due to their contribution to several diseases (Chapter 1). A protocol for the quick isolation of mitochondria from cultured cells and several methods for the characterization of isolated mitochondria were ...


Translation of the abstract (German)

Mitochondrien als intrazelluläre Zielstruktur für die gezielte Applikation von Wirkstoffen waren das Kernthema dieser Dissertation. Sie sind an verschiedenen Erkrankungen beteiligt und rücken immer mehr in den Fokus pharmazeutischer und medizinischer Forschungen. Es wurden verschiedene Protokolle etabliert: Zur Isolierung von Mitochondrien aus Zellkultur, zur Charakterisierung isolierter ...


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