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AAV-plasmid DNA simplifies liver-directed in vivo gene therapy: Comparison of expression levels after plasmid DNA-, adeno-associated virus- and adenovirus-mediated liver transfection

Doenecke, Axel (2013) AAV-plasmid DNA simplifies liver-directed in vivo gene therapy: Comparison of expression levels after plasmid DNA-, adeno-associated virus- and adenovirus-mediated liver transfection. PhD, Universität Regensburg.

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Date of publication of this fulltext: 03 Sep 2013 09:03

Abstract (English)

Background: Successful liver gene therapy depends on efficient gene transfer techniques and long-lasting gene expression after successful transfer. Over the last decades important progress has been made with the introduction of viral vectors using animal models, but their use is hampered by a complex and costly preparation when compared to the simple and cost-effective preparation of plasmid ...

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Translation of the abstract (German)

Hintergrund: Eine erfolgreiche Leber-Gentherapie ist abhängig von effizienten Gentransfer-Techniken und einer lang anhaltende Genexpression nach erfolgreichem Gentransfer. In den letzten Jahrzehnten sind diesbezüglich zwar bedeutende Fortschritte durch die Verwendung von viralen Vektoren in Tiermodellen gemacht worden. Die Verwendbarkeit dieser Vektoren wird jedoch durch komplexe und kostspielige ...

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Export bibliographical data



Item type:Thesis of the University of Regensburg (PhD)
Date:3 September 2013
Referee:Prof. Dr. Edward K. Geissler
Date of exam:27 August 2013
Institutions:Medicine > Lehrstuhl für Chirurgie
Keywords:nonviral gene transfer, naked DNA gene transfer, AAV-plasmid, in-vivo gene therapy, nonviraler Gentransfer, Gentherapie, Plasmid-DNA, AAV
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:28770
Owner only: item control page

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