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DNA hypermethylation and histone modifications downregulate the candidate tumor suppressor gene RRP22 on 22q12 in human gliomas

Schmidt, Natalie, Windmann, Sonja, Reifenberger, Guido and Riemenschneider, Markus J. (2012) DNA hypermethylation and histone modifications downregulate the candidate tumor suppressor gene RRP22 on 22q12 in human gliomas. Brain pathology 22 (1), pp. 17-25.

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Abstract

RRP22 (Ras-related protein on chromosome 22) has been suggested as a candidate tumor suppressor in human cancers. Investigating a panel of 70 human gliomas, we found a frequent decrease in the RRP22 mRNA expression levels (67%), preferentially in high-grade gliomas [World Health Organization (WHO) grades III and IV] as compared with low-grade gliomas (WHO grade II). Moreover, reduced RRP22 mRNA ...

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Item type:Article
Date:2012
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
21631628PubMed ID
10.1111/j.1750-3639.2011.00507.xDOI
Classification:
NotationType
AdultMESH
AgedMESH
Brain Neoplasms/metabolismMESH
Cell Line, TumorMESH
Chromosomes, Human, Pair 22/geneticsMESH
CpG Islands/geneticsMESH
DNA Methylation/geneticsMESH
Down-Regulation/geneticsMESH
FemaleMESH
Gene Expression Regulation, Neoplastic/physiologyMESH
Glioma/metabolismMESH
Histone Deacetylase Inhibitors/pharmacologyMESH
Histones/metabolismMESH
HumansMESH
MaleMESH
Middle AgedMESH
Regulatory Elements, Transcriptional/physiologyMESH
ras Proteins/geneticsMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29173
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