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Targeted therapy for high-grade glioma with the TGF-β2 inhibitor trabedersen: results of a randomized and controlled phase IIb study

Bogdahn, Ulrich ; Hau, Peter ; Stockhammer, G. ; Venkataramana, N. K. ; Mahapatra, A. K. ; Suri, A. ; Balasubramaniam, A. ; Nair, S. ; Oliushine, V. ; Parfenov, V. ; Poverennova, I. ; Zaaroor, M. ; Jachimczak, P. ; Ludwig, S. ; Schmaus, S. ; Heinrichs, H. ; Schlingensiepen, K. H.


This randomized, open-label, active-controlled, dose-finding phase IIb study evaluated the efficacy and safety of trabedersen (AP 12009) administered intratumorally by convection-enhanced delivery compared with standard chemotherapy in patients with recurrent/refractory high-grade glioma. One hundred and forty-five patients with central reference histopathology of recurrent/refractory ...


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