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Targeted therapy for high-grade glioma with the TGF-β2 inhibitor trabedersen: results of a randomized and controlled phase IIb study

Bogdahn, Ulrich, Hau, Peter, Stockhammer, G., Venkataramana, N. K., Mahapatra, A. K., Suri, A., Balasubramaniam, A., Nair, S., Oliushine, V., Parfenov, V., Poverennova, I., Zaaroor, M., Jachimczak, P., Ludwig, S., Schmaus, S., Heinrichs, H. and Schlingensiepen, K-H. (2011) Targeted therapy for high-grade glioma with the TGF-β2 inhibitor trabedersen: results of a randomized and controlled phase IIb study. Neuro-oncology 13 (1), pp. 132-142.

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Abstract

This randomized, open-label, active-controlled, dose-finding phase IIb study evaluated the efficacy and safety of trabedersen (AP 12009) administered intratumorally by convection-enhanced delivery compared with standard chemotherapy in patients with recurrent/refractory high-grade glioma. One hundred and forty-five patients with central reference histopathology of recurrent/refractory ...

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Item type:Article
Date:2011
Additional Information (public):Trabedersen Glioma Study Group
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
21558078PubMed ID
10.1093/neuonc/noq142DOI
Classification:
NotationType
AdultMESH
Antineoplastic Agents/therapeutic useMESH
Brain Neoplasms/pathologyMESH
FemaleMESH
Glioblastoma/pathologyMESH
HumansMESH
International AgenciesMESH
MaleMESH
Middle AgedMESH
Neoplasm Recurrence, Local/pathologyMESH
Oligodeoxyribonucleotides/therapeutic useMESH
Survival RateMESH
Thionucleotides/therapeutic useMESH
Transforming Growth Factor beta2/antagonists & inhibitorsMESH
Treatment OutcomeMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29178
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