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Temozolomide and 13-cis retinoic acid in patients with anaplastic gliomas: a prospective single-arm monocentric phase-II study (RNOP-05)

Grauer, Oliver ; Pascher, Christina ; Hartmann, Christian ; Zeman, Florian ; Weller, Michael ; Proescholdt, Martin A. ; Brawanski, Alexander ; Pietsch, Thorsten ; Wick, Wolfgang ; Bogdahn, Ulrich ; Hau, Peter


The objective of this prospective, monocentric phase-II pilot study was to evaluate toxicity and efficacy of neoadjuvant temozolomide (TMZ) and 13-cis retinoic acid (13-cRA) treatment in patients with newly diagnosed anaplastic gliomas after total or subtotal tumor resection. The primary endpoint of the study was median progression-free survival (PFS). Secondary endpoints were toxicity and PFS ...


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