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Prolonged survival with valproic acid use in the EORTC/NCIC temozolomide trial for glioblastoma

Weller, M. ; Gorlia, T. ; Cairncross, J. G. ; van den Bent, M. J. ; Mason, W. ; Belanger, K. ; Brandes, A. A. ; Bogdahn, Ulrich ; Macdonald, D. R. ; Forsyth, P. ; Rossetti, A. O. ; Lacombe, D. ; Mirimanoff, R.-O. ; Vecht, C. J. ; Stupp, R.


VPA may be preferred over an EIAED in patients with glioblastoma who require an AED during TMZ-based chemoradiotherapy. Future studies are needed to determine whether VPA increases TMZ bioavailability or acts as an inhibitor of histone deacetylases and thereby sensitizes for radiochemotherapy in vivo.

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