Go to content
UR Home

Prolonged survival with valproic acid use in the EORTC/NCIC temozolomide trial for glioblastoma

Weller, M. ; Gorlia, T. ; Cairncross, J. G. ; van den Bent, M. J. ; Mason, W. ; Belanger, K. ; Brandes, A. A. ; Bogdahn, Ulrich ; Macdonald, D. R. ; Forsyth, P. ; Rossetti, A. O. ; Lacombe, D. ; Mirimanoff, R.-O. ; Vecht, C. J. ; Stupp, R.



Abstract

VPA may be preferred over an EIAED in patients with glioblastoma who require an AED during TMZ-based chemoradiotherapy. Future studies are needed to determine whether VPA increases TMZ bioavailability or acts as an inhibitor of histone deacetylases and thereby sensitizes for radiochemotherapy in vivo.


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons