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Butyrate stimulates the early process of the osteogenic differentiation but inhibits the biomineralization in dental follicle cells (DFCs)

URN to cite this document:
urn:nbn:de:bvb:355-epub-292281
Drees, Johannes
Date of publication of this fulltext: 17 Dec 2013 10:35


Abstract (English)

Dental stem cells, especially dental follicle cells (DFCs) as precursor cells for the periodontium have interesting prospects for regenerative dentistry. During periodontitis, butyrate as a bacterial metabolite and inflammatory agent is often found in millimolar concentrations in periodontal pockets. This study evaluates the effects of butyrate on the proliferation and osteogenic differentiation ...

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Translation of the abstract (German)

Dentale Stammzellen, insbesondere dentale Follikelzellen (DFCs) als Vorläuferzellen des Parodonts besitzen vielversprechende Aussichten für regenerative Therapieansätze. Butyrat als bakterieller Metabolit und inflammatorisch aktive Substanz findet sich oftmals in millimolarer Konzentration in aktiven parodontalen Taschen wieder. Diese Studie befasst sich mit dem Einfluss von Butyrat auf den ...

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