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Deficiency of intestinal Mucin-2 ameliorates experimental alcoholic liver disease in mice

URN to cite this document:
urn:nbn:de:bvb:355-epub-292419
Hartmann, Phillipp
Date of publication of this fulltext: 19 Dec 2013 11:06


Abstract (English)

The intestinal mucus layer protects the epithelium from noxious agents, viruses, and pathogenic bacteria present in the gastrointestinal tract. It is composed of mucins, predominantly mucin (Muc) 2, secreted by goblet cells of the intestine. Experimental alcoholic liver disease requires translocation of bacterial products across the intestinal barrier into the systemic circulation, which induces ...

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Translation of the abstract (German)

Die intestinale Schleimschicht schützt das Epithel vor schädlichen Stoffen, Viren und pathogenen Bakterien, die sich im Magen-Darm-Trakt befinden. Sie besteht aus Muzinen, insbesondere Muzin-2 (Muc2), welche von Becherzellen des Darmes sezerniert werden. Experimentelle alkoholische Lebererkrankung erfordert eine Translokation von Bakterienbestandteilen über die Darmwand in die systemische ...

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