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Deficiency of intestinal Mucin-2 ameliorates experimental alcoholic liver disease in mice

Hartmann, Phillipp (2013) Deficiency of intestinal Mucin-2 ameliorates experimental alcoholic liver disease in mice. PhD, Universität Regensburg.

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Date of publication of this fulltext: 19 Dec 2013 11:06

Abstract (English)

The intestinal mucus layer protects the epithelium from noxious agents, viruses, and pathogenic bacteria present in the gastrointestinal tract. It is composed of mucins, predominantly mucin (Muc) 2, secreted by goblet cells of the intestine. Experimental alcoholic liver disease requires translocation of bacterial products across the intestinal barrier into the systemic circulation, which induces ...

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Translation of the abstract (German)

Die intestinale Schleimschicht schützt das Epithel vor schädlichen Stoffen, Viren und pathogenen Bakterien, die sich im Magen-Darm-Trakt befinden. Sie besteht aus Muzinen, insbesondere Muzin-2 (Muc2), welche von Becherzellen des Darmes sezerniert werden. Experimentelle alkoholische Lebererkrankung erfordert eine Translokation von Bakterienbestandteilen über die Darmwand in die systemische ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:19 December 2013
Referee:Prof. Dr. Claus Hellerbrand and PD Dr. Sven Lang
Date of exam:18 December 2013
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Keywords:Mucin-2, Muc2, ALD, alcoholic liver disease, intestinal dysbiosis, intestinal bacterial overgrowth, bacterial translocation, LPS, Reg3b, Reg3g, Muzin-2, alkoholische Lebererkrankung, intestinale Dysbiose, intestinale bakterielle Überwucherung, bakterielle Translokation
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:29241
Owner only: item control page

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