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Multicentre phase II studies evaluating imatinib plus hydroxyurea in patients with progressive glioblastoma

Reardon, D. A., Dresemann, G., Taillibert, S., Campone, M., van den Bent, M., Clement, P., Blomquist, E., Gordower, L., Schultz, H., Raizer, J., Hau, Peter, Easaw, J., Gil, M., Tonn, J., Gijtenbeek, A., Schlegel, U., Bergstrom, P., Green, S., Weir, A. and Nikolova, Z. (2009) Multicentre phase II studies evaluating imatinib plus hydroxyurea in patients with progressive glioblastoma. British journal of cancer 101 (12), pp. 1995-2004.

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Abstract

Imatinib in addition to hydroxyurea was well tolerated among patients with recurrent GBM but did not show clinically meaningful anti-tumour activity.


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Item type:Article
Date:2009
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
19720927PubMed ID
10.1038/sj.bjc.6605411DOI
Classification:
NotationType
AdolescentMESH
Adrenal Cortex Hormones/administration & dosageMESH
AdultMESH
AgedMESH
Antineoplastic Combined Chemotherapy Protocols/therapeutic useMESH
BenzamidesMESH
Brain Neoplasms/drug therapyMESH
FemaleMESH
Glioblastoma/mortalityMESH
HumansMESH
Hydroxyurea/pharmacokineticsMESH
MaleMESH
Middle AgedMESH
Piperazines/pharmacokineticsMESH
Proto-Oncogene Proteins c-kit/geneticsMESH
Pyrimidines/pharmacokineticsMESH
Survival RateMESH
Tumor Markers, Biological/analysisMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29261
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