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Der Zellzyklusregulator Rca1 - Inhibitor und Substrat des Anaphase-Promoting-Komplexes in Drosophila melanogaster

Morgenthaler, Christoph (2014) Der Zellzyklusregulator Rca1 - Inhibitor und Substrat des Anaphase-Promoting-Komplexes in Drosophila melanogaster. PhD, Universität Regensburg.

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Date of publication of this fulltext: 02 Oct 2014 15:50

Abstract (German)

Ein wichtiger Kontrollmechanismus des Zellzyklus ist die irreversible Proteolyse von Zellzyklus-Regulatoren. Dabei markieren E3-Ligasen Zielproteine durch Ubiquitinmoleküle. Für den Abbau in der Mitose und der G1-Phase reguliert der APC/C-Komplex (Anaphase-Promoting-Complex/Cyclosome) als E3-Ligase den zeitlichen Verlauf des Zellzyklus. Die Aktivität des APC/C wiederum wird in den übrigen ...

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Translation of the abstract (English)

For progression through the cell cycle, alternate degradation and accumulation of regulatory proteins are essential. Proteolysis of cell cycle regulators is initiated by E3 ligases that mediate polyubiquitination of substrate molecules. The anaphase-promoting complex/cyclosome (APC/C) is such an ubiquitin-ligase that is active during mitosis and G1-phase but needs to be inactive during S- and ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:2 October 2014
Referee:Prof. Dr. Frank Sprenger and Prof. Dr. Stephan Schneuwly and Prof. Dr. Wolfgang Seufert
Date of exam:6 February 2014
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Cell Cycle Control > Prof. Dr. Frank Sprenger
Keywords:Rca1, Anaphase-Promoting-Komplex, APC, Drosophila melanogaster
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:29450
Owner only: item control page

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