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Luminescent Dual Sensors Reveal Extracellular pH-Gradients and Hypoxia on Chronic Wounds That Disrupt Epidermal Repair

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Schreml, Stephan ; Meier, Robert Johannes ; Kirschbaum, Michael ; Kong, Su-Chii ; Gehmert, Sebastian ; Felthaus, Oliver ; Küchler, Sarah ; Sharpe, Justin R. ; Wöltje, Kerstin ; Weiß, Katharina ; Albert, Markus ; Seidl, Uwe ; Schröder, Josef ; Morsczeck, Christian ; Prantl, Lukas ; Duschl, Claus ; Pedersen, Stine F. ; Gosau, Martin ; Breneburg, Mark ; Wolfbeis, Otto S. ; Landthaler, Michael ; Babilas, Philipp
Date of publication of this fulltext: 22 May 2014 12:06


Wound repair is a quiescent mechanism to restore barriers in multicellular organisms upon injury. In chronic wounds, however, this program prematurely stalls. It is known that patterns of extracellular signals within the wound fluid are crucial to healing. Extracellular pH (pHe) is precisely regulated and potentially important in signaling within wounds due to its diverse cellular effects. ...


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