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Expression and function of methylthioadenosine phosphorylase in chronic liver disease

Czech, Barbara, Dettmer, Katja, Valletta, Daniela, Saugspier, Michael Sebastian, Koch, Andreas, Stevens, Axel Peter, Thasler, Wolfgang E., Müller, Martina, Oefner, Peter J., Bosserhoff, Anja-Katrin and Hellerbrand, Claus (2013) Expression and function of methylthioadenosine phosphorylase in chronic liver disease. PloS ONE 8 (12), e80703.

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Abstract

To study expression and function of methylthioadenosine phosphorylase (MTAP), the rate-limiting enzyme in the methionine and adenine salvage pathway, in chronic liver disease. DESIGN: MTAP expression was analyzed by qRT-PCR, Western blot and immunohistochemical analysis. Levels of MTA were determined by liquid chrmatography-tandem mass spectrometry. RESULTS: MTAP was downregulated in hepatocytes ...

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Item type:Article
Date:December 2013
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Lehrstuhl für Innere Medizin I
Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
8650244PubMed ID
10.1371/journal.pone.0080703DOI
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:30567
Owner only: item control page

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