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Expression and function of methylthioadenosine phosphorylase in chronic liver disease

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Czech, Barbara ; Dettmer, Katja ; Valletta, Daniela ; Saugspier, Michael Sebastian ; Koch, Andreas ; Stevens, Axel Peter ; Thasler, Wolfgang E. ; Müller, Martina ; Oefner, Peter J. ; Bosserhoff, Anja-Katrin ; Hellerbrand, Claus
License: Creative Commons: Attribution 3.0
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Date of publication of this fulltext: 07 Aug 2014 13:27


To study expression and function of methylthioadenosine phosphorylase (MTAP), the rate-limiting enzyme in the methionine and adenine salvage pathway, in chronic liver disease. DESIGN: MTAP expression was analyzed by qRT-PCR, Western blot and immunohistochemical analysis. Levels of MTA were determined by liquid chrmatography-tandem mass spectrometry. RESULTS: MTAP was downregulated in hepatocytes ...


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