A mammalian cell based FACS-panning platform for the selection of HIV-1 envelopes for vaccine development

URN to cite this document:: urn:nbn:de:bvb:355-epub-308615

Wagner, Ralf ; Bruun, Tim-Henrik ; Mühlbauer, Katharina ; Benen, Thomas ; Kliche, Alexander

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Date of publication of this fulltext: 10 Oct 2014 11:07

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Abstract

An increasing number of broadly neutralizing monoclonal antibodies (bnMAb) against the HIV-1 envelope (Env) protein has been discovered recently. Despite this progress, vaccination efforts with the aim to re-elicit bnMAbs that provide protective immunity have failed so far. Herein, we describe the development of a mammalian cell based FACS-panning method in which bnMAbs are used as tools to ...