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Genetic determinants of inter-individual variations in DNA methylation

Wimmer, Julia (2016) Genetic determinants of inter-individual variations in DNA methylation. PhD, Universität Regensburg.

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Date of publication of this fulltext: 06 May 2016 12:00

Abstract (English)

DNA methylation and histone modifications are epigenetic mechanisms that affect the chromatin structure and thus the readout of the underlying DNA sequence. Hence, variations in the DNA methylation profiles of individuals may contribute to phenotypic differences and disease susceptibility. However, the extent of such epigenetic variations is unclear. With regard to DNA methylation, little is ...

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Translation of the abstract (German)

Epigenetische Mechanismen, wie DNA-Methylierung und die post-translationale Modifikation von Histonen, beeinflussen die Chromatinstruktur und damit die Zugänglichkeit und Expression der assoziierten DNA-Sequenz. Individuelle Variationen im DNA-Methylierungsprofil haben damit das Potenzial zu unterschiedlichen Phänotypen und der Anfälligkeit für bestimmte Krankheiten beizutragen. Dennoch ist ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:6 May 2016
Referee:Prof. Dr. Michael Rehli
Date of exam:4 November 2014
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Keywords:epigenetics, DNA methylation, mouse
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:30963
Owner only: item control page

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