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Morphologische und molekulare Untersuchungen zur Funktion von Myocilin und Olfactomedin-1 (Pancortin) in der Netzhaut

Rosenhammer, Bernd (2015) Morphologische und molekulare Untersuchungen zur Funktion von Myocilin und Olfactomedin-1 (Pancortin) in der Netzhaut. PhD, Universität Regensburg.

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Date of publication of this fulltext: 12 Jan 2015 17:53

Abstract (German)

Myocilin und Olfactomedin-1 (Pancortin) sind Proteine der Olfactomedin-Familie, deren Funktionen bisher weitgehend unbekannt sind. In der vorliegenden Arbeit wurde daher mit Hilfe von Myocilin⁻l⁻-Mäusen versucht, Erkenntnisse über deren Funktion zu gewinnen. Da beide Proteine in der Netzhaut lokalisiert sind und im Falle von Myocilin Gen-Mutationen beim Menschen zur schwerwiegenden ...

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Translation of the abstract (English)

Myocilin and Olfactomedin-1 (Pancortin) are two proteins of the Olfactomedin family whose functional properties are widely unknown. Using Myocilin- and Pancortin-deficient mice the aim of this study was to investigate the functional role of those proteins. As both proteins are located within the retina and mutations in the Myocilin gene are associated with glaucoma, a severe desease leading to ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:12 January 2015
Referee:Prof. Dr. Ernst R. Tamm
Date of exam:15 December 2014
Institutions:Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Humananatomie und Embryologie > Prof. Dr. Ernst Tamm
Keywords:Olfactomedine, Netzhaut, Apoptose, Olfactomedin-domain containing proteins, retina, apoptosis
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:31215
Owner only: item control page

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