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Development of a reliable single-cell aCGH suitable for clinical samples

URN to cite this document:
urn:nbn:de:bvb:355-epub-318818
DOI to cite this document:
10.5283/epub.31881
Czyż, Zbigniew Tadeusz
Date of publication of this fulltext: 24 Jun 2015 11:24


Abstract (English)

Disseminated cancer cells (DCCs) and circulating tumor cells (CTCs) comprise oncological precursors of distant metastases. Detailed analysis of these cells bears the potential of identifying key events regulating systemic cancer progression and the occurrence of therapy resistance. However, given their very low abundance and high level of genetic heterogeneity, comprehensive analysis of CTCs and ...

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Translation of the abstract (German)

Es wird angenommen, dass sich die Gründerzellen tödlicher Metastasen unter den disseminierten und zirkulierenden Tumorzellen (Disseminated cancer cells, DCC bzw. circulating tumor cells, CTC) befinden. Detaillierte Analysen dieser Zellen bergen das Potential Schlüsselmechanismen der systemischen Progression von Krebserkrankungen und der Entstehung von Therapieresistenz zu identifizieren. ...

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