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Novel redox indicators for optical detection of NADH

Fomin, Maksim (2017) Novel redox indicators for optical detection of NADH. PhD, Universität Regensburg.

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Date of publication of this fulltext: 02 Jan 2017 07:13

Abstract (English)

The rapid, sensitive, and selective sensing of nicotinamide adenine dinucleotides NAD(P)H is of significant interest for applications in diagnostic assays, synthesis of chiral compounds and drug discovery. The redox couple NAD(P)+/NAD(P)H plays a crucial role in energy metabolism and has been used as a biomarker to detect altered cancer cell metabolism. Furthermore, NAD(P)H detection is desirable ...

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Translation of the abstract (German)

Ein schneller, empfindlicher und selektiver Nachweis von Nicotinamidadenindinukleotid NAD(P)H ist für Anwendungen im Bereich diagnostischer Assays, der Synthese von chiralen Produkten und der Wirkstoffentwicklung von großem Interesse. Das Redoxpaar NAD(P)+/NAD(P)H spielt eine entscheidende Rolle im Energiestoffwechsel und wurde als Biomarker für die Untersuchung des veränderten Stoffwechsels von ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:2 January 2017
Referee:Prof. Dr. Burkhard König
Date of exam:14 January 2016
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie
Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Keywords:cyanine dye, enzymatic assay, redox indicator, NADH, imaging, multicellular tumor spheroid
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:33599
Owner only: item control page

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