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Two-Acceptor Cyanine-Based Fluorescent Indicator for NAD(P)H in Tumor Cell Models

Fomin, Maksim A., Dmitriev, Ruslan I., Jenkins, James, Papkovsky, Dmitri B., Heindl, Dieter and König, Burkhard (2016) Two-Acceptor Cyanine-Based Fluorescent Indicator for NAD(P)H in Tumor Cell Models. ACS Sensors 1, pp. 702-709.

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Abstract

Sensing of intracellular NAD(P)H is important for numerous applications ranging from diagnostic assays to drug discovery. Up to now, investigation of NAD(P)Hdependent pathways in live cells has been restrained by the lack of efficient tools. Toward this goal, we developed a small molecule indicator, which allows both colorimetric and fluorescent NAD(P)H detection in biological samples. The design ...

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Item type:Article
Date:2016
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Identification Number:
ValueType
10.1021/acssensors.5b00315DOI
Keywords:cyanine dye, enzymatic assay, redox indicator, NAD(P)H, imaging, multicellular tumor spheroid
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:33837
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