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Two-Acceptor Cyanine-Based Fluorescent Indicator for NAD(P)H in Tumor Cell Models

Fomin, Maksim A. ; Dmitriev, Ruslan I. ; Jenkins, James ; Papkovsky, Dmitri B. ; Heindl, Dieter ; König, Burkhard



Zusammenfassung

Sensing of intracellular NAD(P)H is important for numerous applications ranging from diagnostic assays to drug discovery. Up to now, investigation of NAD(P)H-dependent pathways in live cells has been restrained by the lack of efficient tools. Toward this goal, we developed a small molecule indicator, which allows both colorimetric and fluorescent NAD(P)H detection in biological samples. The ...

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