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Modulation of TRPV1 function by phosphorylation and site-directed mutagenesis: from structure to biophysics

URN to cite this document:
urn:nbn:de:bvb:355-epub-340954
DOI to cite this document:
10.5283/epub.34095
Jendryke, Thomas
Date of publication of this fulltext: 21 Jul 2016 07:31


Abstract (German)

Der TRPV1 Rezeptor ist ein polymodal aktivierbarer Kationenkanal, der eine besondere Rolle in der Nozizeption einnimmt. Es ist bekannt, dass die positive Modulation der TRPV1 Funktion durch Proteinkinase-vermittelte Phosphorylierungsprozesse zur Ausbildung von Hyperalgesie und/oder Allodynie beiträgt. Die vorliegende Studie hat das Ziel, die funktionellen Auswirkungen der Cdk5-vermittelten ...

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Translation of the abstract (English)

The TRPV1 receptor is a polymodally activated cation channel acting as key receptor in nociceptive neurons. Its function is modulated by kinase-mediated phosphorylation, which contributes to the development of hyperalgesia and allodynia. In the present study, we demonstrate that TRPV1 function is strongly modulated by the Cdk5-mediated phosphorylation at amino acid residue T406. We observed that ...

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