Go to content
UR Home

Modulation of TRPV1 function by phosphorylation and site-directed mutagenesis: from structure to biophysics

Jendryke, Thomas (2016) Modulation of TRPV1 function by phosphorylation and site-directed mutagenesis: from structure to biophysics. PhD, Universität Regensburg.

[img]
Preview
License: Publishing license for publications excluding print on demand
PDF
Download (10MB)
Date of publication of this fulltext: 21 Jul 2016 07:31

Abstract (German)

Der TRPV1 Rezeptor ist ein polymodal aktivierbarer Kationenkanal, der eine besondere Rolle in der Nozizeption einnimmt. Es ist bekannt, dass die positive Modulation der TRPV1 Funktion durch Proteinkinase-vermittelte Phosphorylierungsprozesse zur Ausbildung von Hyperalgesie und/oder Allodynie beiträgt. Die vorliegende Studie hat das Ziel, die funktionellen Auswirkungen der Cdk5-vermittelten ...

plus

Translation of the abstract (English)

The TRPV1 receptor is a polymodally activated cation channel acting as key receptor in nociceptive neurons. Its function is modulated by kinase-mediated phosphorylation, which contributes to the development of hyperalgesia and allodynia. In the present study, we demonstrate that TRPV1 function is strongly modulated by the Cdk5-mediated phosphorylation at amino acid residue T406. We observed that ...

plus


Export bibliographical data



Item type:Thesis of the University of Regensburg (PhD)
Date:21 July 2016
Referee:Prof. Dr. C.H. Wetzel
Date of exam:12 July 2016
Institutions:Medicine > Lehrstuhl für Psychiatrie und Psychotherapie > Molekulare Neurowissenscahften
Keywords:Zellbiologie, Elektrophysiologie, Whole-cell, single-channel, Pain, TRPV1, Cdk5,
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:34095
Owner only: item control page

Downloads

Downloads per month over past year

  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons