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Transient inactivation of the infralimbic cortex induces antidepressant-like effects in the rat

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Slattery, David A. ; Neumann, Inga D. ; Cryan, John F.
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Date of publication of this fulltext: 16 Aug 2016 08:35


Affective disorders are among the main causes of disability worldwide, yet the underlying pathophysiology remains poorly understood. Recently, landmark neuroimaging studies have shown increased metabolic activity in Brodmann Area 25 (BA25) in depressed patients. Moreover, functional inactivation of this region using deep brain stimulation alleviated depressive symptoms in severely depressed ...


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