Transient inactivation of the infralimbic cortex induces antidepressant-like effects in the rat

URN to cite this document:: urn:nbn:de:bvb:355-epub-343104
DOI to cite this document:: 10.5283/epub.34310

Slattery, David A. ; Neumann, Inga D. ; Cryan, John F.

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Date of publication of this fulltext: 16 Aug 2016 08:35

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Abstract

Affective disorders are among the main causes of disability worldwide, yet the underlying pathophysiology remains poorly understood. Recently, landmark neuroimaging studies have shown increased metabolic activity in Brodmann Area 25 (BA25) in depressed patients. Moreover, functional inactivation of this region using deep brain stimulation alleviated depressive symptoms in severely depressed ...