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Antibody masked cytokines as new approach in targeted tumor therapy

Kuen, Martin Matthias (2018) Antibody masked cytokines as new approach in targeted tumor therapy. PhD, Universität Regensburg.

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Date of publication of this fulltext: 07 Aug 2018 05:35

Abstract (English)

Cytokine-based cancer therapies are commonly applied treatment strategies in oncology. A prominent representative of this potent class of anti-tumor agents is interferon alpha. Interferon is well known for its anti-viral and anti-proliferative activities and a potent therapeutic agent in the treatment of multiple myeloma, chronic myeloid leukemia (CML), hairy cell leukemia (HCL) and malignant ...

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Translation of the abstract (German)

Heutzutage kommen diverse Zykokine in der Therapie von soliden Tumoren und Leukämien zum Einsatz. Ein prominenter Vertreter jener Klasse von Signalmolekülen ist Interferon alpha. Interferon alpha ist bekannt für seine anti-virale und anti-proliferative Wirkung, wodurch es in diversen onkologischen Indikationen zum Einsatz kommt. Die Verabreichung hoher Dosen jenes Zytokins, geht meist jedoch mit ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:7 August 2018
Referee:Prof. Dr. Daniela Männel and Prof. Dr. Jörg Heilmann and PD Dr. Miriam Breunig
Date of exam:5 August 2016
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Keywords:Cytokines, Interferon, fusion protein, proteases, CD138, CrossMab, Multiple Myeloma
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:34646
Owner only: item control page

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