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Antibody masked cytokines as new approach in targeted tumor therapy

URN to cite this document:
urn:nbn:de:bvb:355-epub-346463
DOI to cite this document:
10.5283/epub.34646
Kuen, Martin Matthias
Date of publication of this fulltext: 07 Aug 2018 05:35


Abstract (English)

Cytokine-based cancer therapies are commonly applied treatment strategies in oncology. A prominent representative of this potent class of anti-tumor agents is interferon alpha. Interferon is well known for its anti-viral and anti-proliferative activities and a potent therapeutic agent in the treatment of multiple myeloma, chronic myeloid leukemia (CML), hairy cell leukemia (HCL) and malignant ...

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Translation of the abstract (German)

Heutzutage kommen diverse Zykokine in der Therapie von soliden Tumoren und Leukämien zum Einsatz. Ein prominenter Vertreter jener Klasse von Signalmolekülen ist Interferon alpha. Interferon alpha ist bekannt für seine anti-virale und anti-proliferative Wirkung, wodurch es in diversen onkologischen Indikationen zum Einsatz kommt. Die Verabreichung hoher Dosen jenes Zytokins, geht meist jedoch mit ...

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