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Analysis of the Immune Cell Infiltrates and Biomarkers during acute Gastrointestinal Graft vs Host Disease

Ghimire, Sakhila (2017) Analysis of the Immune Cell Infiltrates and Biomarkers during acute Gastrointestinal Graft vs Host Disease. PhD, Universität Regensburg.

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Date of publication of this fulltext: 22 Dec 2016 05:43

Abstract (English)

Our understanding in GvHD biology has advanced substantially; yet, the pathophysiology of gut GvHD is poorly understood partially due to the lack of gut biopsies for research and the difficulties to directly translate data from murine experiments into humans. The aim of this dissertation was therefore to analyze immune cell infiltrates and biomarkers in gut biopsies of patients after allogenic ...

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Translation of the abstract (German)

In der Pathophysiologie der GvHD stand bis vor kurzem die Aktivierung alloreaktiver zytotoxischer T Zellen des Spenders durch major und minor HLA Antigene des Empfängers im Vordergrund. In einer ersten Phase werden diese auf Empfänger Antigenpräsentierenden Zellen nach Aktivierung durch die Konditionierung und Danger Associated Patterns stimuliert. In der Effektorphase werden die Targetorgane der ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:22 December 2017
Referee:Prof. Dr. Ernst Holler
Date of exam:12 December 2016
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Keywords:GvHD, T regs, ILCs, mikrobiome
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:34999
Owner only: item control page

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