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Untersuchung der molekularen Valproinsäure-Effekte auf Gliom-Zellen

Hoja, Sabine (2017) Untersuchung der molekularen Valproinsäure-Effekte auf Gliom-Zellen. PhD, Universität Regensburg.

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Date of publication of this fulltext: 16 Jan 2017 06:14

Abstract (German)

Viele Glioblastom-Patienten leiden an epileptischen Anfällen, weshalb sie mit Antiepileptika, die dann zusätzlich zu chemotherapeutischen Medikamenten verabreicht werden, behandelt werden. Die Valproinsäure (VPA) ist ein Histon-Deacetylase-Inhibitor (HDACi), der neben seinen antikonvulsiven Effekten auch eine Anti-Krebs-Wirkung besitzt: In einigen retrospektiven Studien konnte gezeigt werden, ...

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Translation of the abstract (English)

Many glioblastoma patients suffer from seizures why they are treated with antiepileptic agents. Valproic acid (VPA) is a histone deacetylase inhibitor that apart from its anticonvulsive effects in some retrospective studies has been suggested to lead to a superior outcome of glioblastoma patients. However, the exact molecular effects of VPA treatment on glioblastoma cells have not yet been ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:16 January 2017
Referee:Prof. Dr. Markus J. Riemenschneider
Date of exam:11 January 2017
Institutions:Medicine > Abteilung für Neuropathologie
Keywords:brain cancer, glioblastoma, temozolomide, HDAC inhibitors, SLC transporters
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:35048
Owner only: item control page

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