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Abnormal vessel formation in the choroid of mice lacking tissue inhibitor of metalloprotease-3

Janssen, A. ; Hoellenriegel, J. ; Fogarasi, M. ; Schrewe, H. ; Seeliger, M. ; Tamm, Ernst R. ; Ohlmann, Andreas ; May, C. A. ; Weber, Bernhard H. F. ; Stöhr, Heidi


PURPOSE: Tissue inhibitor of metalloprotease (TIMP)-3 is an inhibitor of matrix metalloprotease (MMP) and regulates angiogenesis. In the eye, TIMP3 is tightly associated with Bruch's membrane. In this study, the authors analyzed mice lacking TIMP3 for retinal abnormalities. METHODS: Mice with targeted disruption of the Timp3 gene were generated (Timp3(-/-)) and bred into C57/Bl6 and CD1 ...


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