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Abnormal vessel formation in the choroid of mice lacking tissue inhibitor of metalloprotease-3

Janssen, A., Hoellenriegel, J., Fogarasi, M., Schrewe, H., Seeliger, M., Tamm, Ernst R. , Ohlmann, Andreas , May, C. A., Weber, Bernhard H. F. and Stöhr, Heidi (2008) Abnormal vessel formation in the choroid of mice lacking tissue inhibitor of metalloprotease-3. Investigative Ophthalmology & Visual Science (IOVS) 49, pp. 2812-2822.

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Abstract

PURPOSE: Tissue inhibitor of metalloprotease (TIMP)-3 is an inhibitor of matrix metalloprotease (MMP) and regulates angiogenesis. In the eye, TIMP3 is tightly associated with Bruch's membrane. In this study, the authors analyzed mice lacking TIMP3 for retinal abnormalities. METHODS: Mice with targeted disruption of the Timp3 gene were generated (Timp3(-/-)) and bred into C57/Bl6 and CD1 ...

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Item type:Article
Date:2008
Institutions:Medicine > Lehrstuhl für Humangenetik
Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Humananatomie und Embryologie > Prof. Dr. Ernst Tamm
Identification Number:
ValueType
10.1167/iovs.07-1444DOI
18408187PubMed ID
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:35153
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