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Induction of Early Growth Response-1 Mediates Microglia Activation In Vitro But is Dispensable In Vivo

Langmann, Thomas ; Ebert, Stefanie ; Walcak, Y. ; Weigelt, K. ; Ehrengruber, M. U. ; Stiewe, T. ; Weber, Bernhard H. F.



Abstract

Age-related macular degeneration (AMD) is a frequent, multifactorial disease of the central retina and a major cause of irreversible vision loss in industrialized countries. Apolipoprotein E (APOE) has been consistently associated with AMD, particularly its two functional isoforms E2 (predisposing) and E4 (protective). The biological correlate of this association, however, is still unclear. In ...

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