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CRX controls retinal expression of the X-linked juvenile retinoschisis (RS1) gene

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Langmann, Thomas ; Lai, C. C. ; Weigelt, K. ; Tam, B. M. ; Warneke-Wittstock, R. ; Moritz, O. L. ; Weber, Bernhard H. F.
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Date of publication of this fulltext: 10 Feb 2017 15:24


X-linked juvenile retinoschisis is a heritable condition of the retina in males caused by mutations in the RS1 gene. Still, the cellular function and retina-specific expression of RS1 are poorly understood. To address the latter issue, we characterized the minimal promoter driving expression of RS1 in the retina. Binding site prediction, site-directed mutagenesis, and reporter assays suggest an ...


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