CRX controls retinal expression of the X-linked juvenile retinoschisis (RS1) gene

URN to cite this document:: urn:nbn:de:bvb:355-epub-352116
DOI to cite this document:: 10.5283/epub.35211

Langmann, Thomas ; Lai, C. C. ; Weigelt, K. ; Tam, B. M. ; Warneke-Wittstock, R. ; Moritz, O. L. ; Weber, Bernhard H. F.

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Date of publication of this fulltext: 10 Feb 2017 15:24

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Abstract

X-linked juvenile retinoschisis is a heritable condition of the retina in males caused by mutations in the RS1 gene. Still, the cellular function and retina-specific expression of RS1 are poorly understood. To address the latter issue, we characterized the minimal promoter driving expression of RS1 in the retina. Binding site prediction, site-directed mutagenesis, and reporter assays suggest an ...