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The role of caspases in photoreceptor cell death of the retinoschisin-deficient mouse

Gehrig, A. ; Janssen, A. ; Horling, F. ; Grimm, C. ; Weber, Bernhard H. F.



Abstract

Early schisis cavities in the retinal bipolar cell layer accompanied by progressive loss of cone and rod photoreceptor cells are the hallmark of the retinoschisin-deficient (Rs1h–/Y) murine retina. With this study we aimed at elucidating the molecular events underlying the photoreceptor cell death in this established murine model of X-linked juvenile retinoschisis. We show that photoreceptor ...

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