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LOV domain signaling: A study of LOV-LOV interactions

Magerl, Kathrin (2018) LOV domain signaling: A study of LOV-LOV interactions. PhD, Universität Regensburg.

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Date of publication of this fulltext: 23 Apr 2018 05:06

Abstract (German)

Die vorliegende Arbeit befasst sich mit der Signalentstehung und –weiterleitung in LOV (light-, oxygen- or voltage-sensitive) Domänen. Durch die Absorption von blauem oder nahem UV-Licht bilden diese Blaulichtphotorezeptoren ein Flavin-Cysteinyl-Addukt, welches den Signalzustand des Proteins darstellt. Durch die Adduktbildung werden dynamische und strukturelle Änderungen in der LOV Domäne ...

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Translation of the abstract (English)

This thesis deals with LOV (light-, oxygen- or voltage-sensitive) domain signaling. These blue light photoreceptors form a flavin-cysteinyl-adduct as the signaling state upon absorption of blue or near UV light. Adduct formation induces dynamic and structural changes in the LOV domain which regulate the physiological function of the protein. In the first part of this thesis the photochemistry of ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:23 April 2018
Referee:Prof. Dr. Bernhard Dick and PD Dr. Tilman Kottke
Date of exam:21 April 2017
Institutions:Chemistry and Pharmacy > Institut für Physikalische und Theoretische Chemie > Chair of Chemistry III - Physical Chemistry (Molecular Spectroscopy and Photochemistry) > Prof. Dr. Bernhard Dick
Keywords:LOV domains, Protein signaling, Spectroscopy, Förster Resonance Energy Transfer
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:35612
Owner only: item control page

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