Effects of Mesenchymal Stem Cell and Growth Factor Delivery on Cartilage Repair in a Mini-Pig Model

URN to cite this document:: urn:nbn:de:bvb:355-epub-356350
DOI to cite this document:: 10.5283/epub.35635

Fisher, Matthew B. ; Belkin, Nicole S. ; Milby, Andrew H. ; Hennig, Elizabeth A. ; Soegaard, Nicole ; Minwook, Kim ; Pfeifer, Christian

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Date of publication of this fulltext: 09 May 2017 09:34

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Abstract

Objective We have recently shown that mesenchymal stem cells (MSCs) embedded in a hyaluronic acid (HA) hydrogel and exposed to chondrogenic factors (transforming growth factor-3 [TGF-3]) produce a cartilage-like tissue in vitro. The current objective was to determine if these same factors could be combined immediately prior to implantation to induce a superior healing response in vivo relative to ...