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Molecular mechanism of early metastatic breast cancer dissemination

Hosseini, Hedayatollah (2017) Molecular mechanism of early metastatic breast cancer dissemination. PhD, Universität Regensburg.

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Date of publication of this fulltext: 06 Jun 2017 10:28

Abstract (English)

Current cancer therapies generally assume cancers to progress linearly from primary to metastatic sites. The model postulates a stepwise accumulation of genetic and epigenetic alterations within the primary tumor, and therefore, primary tumors may be used as surrogate markers for disseminated cancer cells. However, this model is challenged by (i) the insufficient therapy success and (ii) the ...

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Translation of the abstract (German)

Etwa 90% der krebsbedingten Todesfälle werden durch Metastasen verursacht. Ein tieferes Verständnis der Streuung und dem Auswachsen von Krebszellen in Zielorganen ist wichtig, um zukünftig bessere Behandlungsmethoden entwickeln zu können. Wir konnten nachweisen, dass die Streuung von Krebszellen in einem Brustkrebsmodell (dem Her2 getriebenen Mausmodell BALB-NeuT) schon bei sehr frühen ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:6 June 2017
Referee:Prof. Dr. Christoph A. Klein and Prof. Dr. Gunter Meister and Prof. Dr. Richard Warth
Date of exam:24 March 2017
Institutions:Medicine > Lehrstuhl für experimentelle Medizin und Therapieverfahren
Keywords:Breast cancer, early dissemination, Metastasis, Her2, PGR, miRNA
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:35734
Owner only: item control page

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