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CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD

URN to cite this document:
urn:nbn:de:bvb:355-epub-358606
DOI to cite this document:
10.5283/epub.35860
Scholl, H. P. ; Fleckenstein, M. ; Fritsche, L. G. ; Schmitz-Valckenberg, S. ; Göbel, A. ; Adrion, C. ; Herold, C. ; Keilhauer, C. N. ; Mackensen, F. ; Mössner, A. ; Pauleikhoff, D. ; Weinberger, A. W. ; Mansmann, U. ; Holz, F. G. ; Becker, T. ; Weber, Bernhard H. F.
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Date of publication of this fulltext: 07 Jul 2017 11:45


Abstract

Background Age-related macular degeneration (AMD) is a prevalent cause of blindness in Western societies. Variants in the genes encoding complement factor H (CFH), complement component 3 (C3) and age-related maculopathy susceptibility 2 (ARMS2) have repeatedly been shown to confer significant risks for AMD; however, their role in disease progression and thus their potential relevance for ...

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