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Prolonged recovery of retinal structure/function after gene therapy in an Rs1h-deficient mouse model of X-linked juvenile retinoschisis

Min, S H, Molday, L L, Seeliger, M W, Dinculescu, A, Timmers, A M, Janssen, A, Tonagel, F, Tanimoto, N, Weber, Bernhard H. F. , Molday, R S and Hauswirth, W W (2005) Prolonged recovery of retinal structure/function after gene therapy in an Rs1h-deficient mouse model of X-linked juvenile retinoschisis. Molecular Therapy 12 (4), pp. 644-651.

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Date of publication of this fulltext: 28 Jul 2017 08:49

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Abstract

X-linked juvenile retinoschisis (RS) is a common cause of juvenile macular degeneration in males. RS is characterized by cystic spoke-wheel-like maculopathy, peripheral schisis, and a negative (b-wave more reduced than a-wave) electroretinogram (ERG). These symptoms are due to mutations in the RS1 gene in Xp22.2 leading to loss of functional protein. No medical treatment is currently available. ...

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Item type:Article
Date:2005
Institutions:Medicine > Lehrstuhl für Humangenetik
Identification Number:
ValueType
10.1016/j.ymthe.2005.06.002DOI
16027044PubMed ID
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:35918
Owner only: item control page

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