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Polymorphisms in the Janus kinase 2 (JAK)/signal transducer and activator of transcription (STAT) genes: putative association of the STAT gene region with familial breast cancer

Vaclavicek, A, Bermejo, J L, Schmutzler, R K, Sutter, C, Wappenschmidt, B, Meindl, A, Kiechle, M, Arnold, N, Weber, Bernhard H. F. , Niederacher, D, Burwinkel, B, Bartram, C R, Hemminki, K and Försti, A (2007) Polymorphisms in the Janus kinase 2 (JAK)/signal transducer and activator of transcription (STAT) genes: putative association of the STAT gene region with familial breast cancer. Endocrine related cancer 14 (2), pp. 267-277.

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Other URL: http://erc.endocrinology-journals.org/content/14/2/267.long


Abstract

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway mediates the signals of a wide range of cytokines, growth factors and hormones. Thus, aberrant activation of the JAK/STAT pathway may predispose to malignancy due to deregulation of proliferation, differentiation or apoptosis. In this study, we investigated whether genetic variation in the JAK2 gene and the ...

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Item type:Article
Date:2007
Institutions:Medicine > Lehrstuhl für Humangenetik
Identification Number:
ValueType
10.1677/ERC-06-0077DOI
17639043PubMed ID
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:35927
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