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Dextran and protamine-based solid lipid nanoparticles as potential vectors for the treatment of X-linked juvenile retinoschisis

Delgado, D. ; del Pozo-Rodríguez, A. ; Solinís, M. A. ; Avilés-Triqueros, M. ; Weber, Bernhard H. F. ; Fernández, E. ; Gascón, A. R.


The goal of the present study was to analyze the potential application of nonviral vectors based on solid lipid nanoparticles (SLN) for the treatment of ocular diseases by gene therapy, specifically X-linked juvenile retinoschisis (XLRS). Vectors were prepared with SLN, dextran, protamine, and a plasmid (pCMS-EGFP or pCEP4-RS1). Formulations were characterized and the in vitro transfection ...


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