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Analysis of the significance of miRNAs of the miRNA-200 family in the malignant phenotype of glioblastoma

Vélez Char, Natalia (2017) Analysis of the significance of miRNAs of the miRNA-200 family in the malignant phenotype of glioblastoma. PhD, Universität Regensburg.

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Date of publication of this fulltext: 08 Aug 2017 05:29

Abstract (English)

The miR200 family has been described to exert tumor suppressing functions in different malignant epithelial tumors, and their down regulation has been associated with aggressiveness, metastatic disease, tumor progression, chemoresistance und worse prognosis. In glioblastoma, some members of the miR200 family have been shown to be expressed at very low levels, and this phenomenon has been ...

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Translation of the abstract (German)

Der miR200-Familie werden Tumorsuppressor-Eigenschaften in verschiedenen malignen epithelialen Tumoren zugeschrieben. Ihre Herunterregulation ist mit Tumoraggressivität, metastatischer Erkrankung, Tumorprogression, Chemoresistenz und schlechterer Prognose assoziiert. Im Glioblastom wurde gezeigt, dass einige Mitglieder der miR200-Familie auf sehr niedrigem Niveau exprimiert werden, und dieses ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:8 August 2017
Referee:Prof. Dr. Markus J. Riemenschneider and Prof. Dr. Peter Hau
Date of exam:2 August 2017
Institutions:Medicine > Abteilung für Neuropathologie
Keywords:miRNA, GBM, EMT, ZEB1/ ZEB2, NGS
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36072
Owner only: item control page

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