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Analysis of the significance of miRNAs of the miRNA-200 family in the malignant phenotype of glioblastoma

URN to cite this document:
urn:nbn:de:bvb:355-epub-360726
DOI to cite this document:
10.5283/epub.36072
Vélez Char, Natalia
Date of publication of this fulltext: 08 Aug 2017 05:29


Abstract (English)

The miR200 family has been described to exert tumor suppressing functions in different malignant epithelial tumors, and their down regulation has been associated with aggressiveness, metastatic disease, tumor progression, chemoresistance und worse prognosis. In glioblastoma, some members of the miR200 family have been shown to be expressed at very low levels, and this phenomenon has been ...

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Translation of the abstract (German)

Der miR200-Familie werden Tumorsuppressor-Eigenschaften in verschiedenen malignen epithelialen Tumoren zugeschrieben. Ihre Herunterregulation ist mit Tumoraggressivität, metastatischer Erkrankung, Tumorprogression, Chemoresistenz und schlechterer Prognose assoziiert. Im Glioblastom wurde gezeigt, dass einige Mitglieder der miR200-Familie auf sehr niedrigem Niveau exprimiert werden, und dieses ...

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